Abstract Background The deregulated alternative splicing of key glycolytic enzyme, Pyruvate Kinase muscle isoenzyme (PKM) is implicated in metabolic adaptation of cancer cells.The splicing switch from normal PKM1 to cancer-specific PKM2 isoform allows the cancer cells to meet their energy and biosynthetic demands, thereby facilitating the cancer ce

Abstract Belt Background Assertive Community Treatment (ACT) is a well-defined service delivery model for the care and treatment of the most severely mentally ill in the community with American origins.The Dutch have adapted the model in order to accommodate a broader range of needs Lawn and allow more flexible implementation.Functional Assertive C

Starting from a reflection on the importance of Spanish revolutionary model in liberal and Hair Accessories romantic Europe and the Spanish Constitution of 1812 influence in that context, the article discusses the specific case of two proposals for adapting the Spanish code in Italy before unification.The first, of Neapolitan origin and anonymous a

The optical coupling efficiency of surface plasmon resonance (SPR) based sensors is theoretically investigated from the first principle.Analytical expressions for the instantaneous electric flux lines associated with the TM modes of a three-layer dielectric-metal-dielectric (DMD) waveguide structure are calculated.It is shown that these electric fl

Emitters of single photons are essential resources for emerging quantum technologies and VOLUME CREAM developed within different platforms including nonlinear optics and atomic and solid-state systems.The energy-level structures of emission processes are critical for reaching and controlling high-quality sources.The most commonly applied test uses